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Last update: 2024-04-28
I don't know much about painkillers in LMICs, but in my understanding the US prescribes many more opioids than other western countries (like Germany, where I'm from). So this idea/problem might be specific to the US.
@mincho: How does Suzetrigine compare to existing non-opioid painkillers?
For anyone interested in how to go from research to large-scale production, there recently was an article about that in Works in Progress: https://worksinprogress.co/issue/getting-materials-out-of-the-lab/
Update: We'll be joining forces with the Qualia Research Institute, who are in Berlin this week: https://qualiacomputing.com/2024/05/17/qri-in-germany/
I think we'll get along great and there's a big overlap. Scott:
The Qualia Research Institute is doing absolutely picture-perfect mad science.
Just an info, nothing actually changes!
Thanks for sharing!
Are the numbers comparable to GiveWell, or is one of them more conservative? One data point could be Malaria. Is the Benefit-to-cost ratio GiveWell calculates for e.g. AMF around 48 as well?
Malaria
Paper: Benefits and Costs of Scaling up Coverage and Use of Insecticide Treated Nets.
Benefit-to-cost ratio: 48.
Investment:
>Scale up coverage of long-lasting insecticidal bed nets coverage to 10 percentage points above the 2019 level. Use of chlorfenapir to offset insecticide resistance and social and behavioral change communication to increase the usage including hang-up campaigns.
Very interesting, thanks for the analysis!
To me especially Figure 3 is important, it's insane how much food goes unharvested and how bad animals are at producing food.
Is there also a version that uses kcal instead of tons and that breaks down animal products into meat and vegetarian?