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Rasool

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To anyone skimming this, this has nothing to do with former OpenAI board member Helen Toner, but rather a paper by an unrelated person with the last name Toner-Rodgers

The UK Health Secretary in 2021, Matt Hancock, ordered 100m vaccines, rather than 30m, because of the film Contagion

https://x.com/LBC/status/1356882697222836226

Dollar Cost Averaging reduces volatility

 

Investing as a lump sum supposedly beats DCA even when adjusting for risk, via the Bogleheads forum, referencing a Vanguard study

There is also this (publicly listed) talk from 2022:
 

Note that the old[1] o3-high that was tested on ARC-AGI-1:

  1. ^

    OpenAI have stated that the newly-released o3 is not the same one as was evaluated on ARC-AGI-1 in December

I subscribe to new posts from someone, and I got this in the notification dropdown

In the email notification it did have the full title in the subject

Though in the email notification, I would have liked it to have some context like "New post by a user you subscribe to: ", it just had the full post title as the subject, no other information

The Center for Global Development has a blog post from December talking about the vaccine rollout which I have been meaning to post on the EA forum with a summary and thoughts but in the meantime here is an AI-assisted overview:

Key Takeaways:

  • The Opportunity: Two new malaria vaccines (RTS,S and R21) are a major scientific breakthrough. Gavi currently plans to vaccinate 52 million children by 2030, potentially saving 180,000 lives.
  • The Gap: However, under current slow rollout plans, ~2.5 million children will still die from malaria unvaccinated by 2030. Faster, broader deployment of these vaccines could prevent an additional ~800,000 child deaths by then.
  • Cost-Effectiveness: The R21 vaccine appears highly cost-effective, estimated at ~$4,200 per life saved (including rollout costs). This rivals top global health interventions. It's significantly cheaper ($3.90/dose) and has much higher production capacity (~100M doses/year) than RTS,S ($9.80/dose, ~8M doses/year), with similar reported efficacy.
  • Bottlenecks to Scale:
    1. Funding: A major funding gap exists for both vaccine procurement (~$1.1B-$1.7B needed beyond current plans for full infant coverage) and crucially, for rollout/delivery (~$500M-$1B+, based on pilot costs).
    2. Vaccine Choice: Prioritizing the more expensive, supply-constrained RTS,S over the cheaper, readily available R21 limits the number of lives saved per dollar spent.
    3. Eligibility Rules: Nigeria (1/3 of global malaria deaths) and Angola are largely ineligible for Gavi support due to income thresholds, massively hindering impact in high-burden areas.
    4. Rollout Strategy: Current plans focus on gradual infant rollouts. A faster "catch-up" campaign including older children (up to 5 years, as WHO guidance allows) could save significantly more lives sooner, but requires more upfront funding and logistical capacity.

The Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD) often has higher estimates for Malaria deaths than the WHO.

For instance in 2021, the WHO estimated 619,000 deaths globally from Malaria, whereas IHME had 748,000

There is a comparison (and much more other interesting data) on the Our World in Data Malaria page

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