A LOT of global health orgs, both big and small. I'm global health there's a decent amount of focus on cost effectiveness as is. Many orgs Givewell funds (miraclefeet a great example) scale cost effective solutions, but aren't part of the EA community at all.
I would say though EA is aware of many of those global health orgs, although I'm sure there are some that aren't so much on the radar.
Probably many people know these and also I wouldn’t say any of them are extremely aligned but since there are no comments.
The various arpa orgs
Congressional budget office
Institute for progress
Market shaping accelerator
Ethical humanist society