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AI Use Note: Main body text entirely human written. Claude (Opus 4.8) helped develop models of animal life histories in the appendix.
Cross-posted from Good Structures.
Executive Summary
* Animal advocates sometimes make claims like “there are X of this animal...
Summary
Back in November 2023 I posted here to launch Spiro and raise our first $198k. Two and a half years later this is an update and a fundraiser for the next step.
The short version: we've now reached over-5,900 people with TB preventive medicine, including over 3,000 children under five years old. Our early results have held up well an...
Adapted from my Substack, Funding Anthropalypse.
Short version: if you want a share of the coming Anthropic and OpenAI windfall - the $37bn+ that could be in play next year - the way in is to become 'legibly excellent', so the evaluators and donors that frontier lab staff already trust point them to yo...
Recent opportunities to take action
I’d be keen for great people to apply to the Deputy Director role ($180-210k/y, remote) at the Mirror Biology Dialogues Fund. I spoke a bit about mirror bacteria on the 80k podcast, James Smith also had a recent episode on it. I generally think this is among the most important roles in the biosecurity space and I’ve been working with the MBDF team for a while now and am impressed by what they’re getting done.
People might be surprised to hear that I put ballpark 1% p(doom) on mirror bacteria alone at the start of 2024. That risk has been cut substantially by the scientific consensus that has formed against building it since then, but there is some remaining risk that the boundaries are not drawn far enough from the brink that bad actors could access it. Having a great person in this role would help ensure a wider safety margin.