A lot of this is going to rest on your specific moral views and the way you define the question, rather than historical factual issues, I suspect.
- The clearest examples are going to be things like genocides and wars. For example, the An Lushan Rebellion was (arguably?) responsible for the largest fraction of humanity to be killed in on event. There have been enough of these that you could fill a very respectable list.
- If you relax your definition of what constitutes an event, things like 'all murder ever' are going to qualify. But these are clearly less dense in space-time than genocides, and many people would not count them as 'an event'.
- If you accept events that are less bad per capita, but more widespread, things like the denial of education to women, which has been quite common, and could plausibly qualify.
- If you think that government acts should be judged similarly to private ones, mass taxation, conscription, imprisonment and immigration restrictions might qualify.
- If you accept more indirect responsibility, the failure to accelerate technological development resulted in hundreds of millions of unnecessary deaths from disease.
- If you believe in a right to a competent electorate, voters supporting predictably incompetent or immoral governments could qualify.
- If you accept ex ante rather than ex post catastrophes, early nuclear testing, where there was a plausible risk the atmosphere might catch fire, could qualify, though maybe the responsibility is not widespread enough.
- If you accept victims other than adult humans, things like factory farming and abortion will qualify.
- If you assign a lot of weight to children's preferences, mandatory schooling which forces them into strict compliance for most of the day could qualify.
The practice of foot binding stands out for me. It originated in China as early as the 10th century, and remained commonplace up until the early 20th. Foot binding was painful and permanently disabling, and rendered women effectively housebound and wholly dependent on their husbands.
From the tiny amount I've read, it sounds like the practice was sustained for so long through some combination of (Neo-)Confucian attitudes, and its entrenched role as a marker of beauty / femininity / honour / national identity which was only really possible to escape collectively — similar to less terrible but more familiar examples of harmful beauty standards. Top-down enforcement was not entirely necessary: the Shunzhi Emperor of the Qing dynasty even tried to abolish the practice, but failed partly owing to its popular support.
The especially sad thing is how contingent its origins seem to be — upper-class women began to imitate a story about a court dancer to the emperor, who reputedly bound her feet "into the shape of a new moon". The practice took hold as a status symbol among the elite, and spread throughout China.
I would be confident in saying at least half a billion women were subjected to this. One estimate claims some 2 billion women broke and bound their feet in total.
This makes me wonder if current hair removal/depilation methods for women could fit the definition (or curious why they would not). We could think of them as minor inconveniences, but maybe women perceived foot binding as a minor inconvenience too (I can think of examples in which we don't categorize things as major inconveniences even when they have huge levels of pain).