Good question! I share that intuition that preventing harm is a really good thing to do, and I find striking the right balance between self-sacrifice and pursuing my own interests difficult.
I think if you argue that that leads to anything close to a normal life you are being disingenuous
I think this is probably wrong for most people. If you make yourself unhappy by trying to force yourself to make sacrifices you don't want to make, I think most people will be much less productive. And I think that most people actually need a fairly normal social life etc. to avoid that. I believe this because I've seen and heard stories of people burning out from trying to work too hard, and I've come close myself.
I think the best way to have a large impact probably looks like working as hard as you sustainably can (for most people, I think this is working hard in a normal 9-5 work week or less), and spending enough time thinking seriously about the best strategy for you to make the biggest difference. It might also involve donating money, but again I think it's a good use of money to spend some money on what makes you happy, to prevent resentment and burn out.
I anticipate that others will say that you are not obligated to live your life to help others. I disagree, and think that we are obligated to do so. I agree that there is often very little difference between acting to do something that harms conscious beings and failing to do something that you are capable of doing that you know will prevent harm.
However, if you do not take care of yourself, you will (a) be less productive and (b) risk burnout and abandoning your commitment to help others. Even if you aspire to do the most good, without privileging your own interests, it is still prudent to make sure that your basic needs are met so that you are most likely to be be able and willing to do the most good throughout the course of your life.