Andreas Mogensen, a Senior Research Fellow at the Global Priorities Institute, has just published a draft of a paper on "Maximal Cluelessness". Abstract:
I argue that many of the priority rankings that have been proposed by effective altruists seem to be in tension with apparently reasonable assumptions about the rational pursuit of our aims in the face of uncertainty. The particular issue on which I focus arises from recognition of the overwhelming importance and inscrutability of the indirect effects of our actions, conjoined with the plausibility of a permissive decision principle governing cases of deep uncertainty, known as the maximality rule. I conclude that we lack a compelling decision theory that is consistent with a long-termist perspective and does not downplay the depth of our uncertainty while supporting orthodox effective altruist conclusions about cause prioritization.
I agree. More specifically, I think the argument for cluelessness is defeatable, and tentatively think that we know of defeaters in some cases. Concretely, I think that we are justified in believing in the positive expected value of (i) avoiding human extinction and (ii) acquiring resources for longtermist goals. (Though I do think that for none of these it is obvious that their expected value is positive, and that considering either to be obvious would be a serious epistemic error.)
I think you overstate your case here. I agree in principle that "the level of uncertainty will always be almost entirely dependent on the facts about the particular case," and so that whether we are clueless about any particular decision is a contingent question. However, I think that inspecting the arguments for cluelessness about, say, the effects of donations to AMF do suggest that cluelessness will be pervasive, for reasons we are in principle able to isolate. To name just one example, many actions will have small but in expectation non-zero, highly uncertain effect on the pace of technological growth; this in turn will have an in expectation non-zero, highly uncertain net effect on the risk of human extinction, which in turn ... - I believe this line of reasoning alone could be fleshed out into a decisive argument for cluelessness about a wide range of decisions.