Michael Nielsen has a beautiful new essay on moral imagination: the ability humans have to 'develop and transmit new notions of good action, indeed, even new kinds of good'.
As examples, he gives:
* Hammurabi's creation of a code of laws (in 1754 BCE) and his justification of his rule not in terms of divine or hereditary right, but by the delivery of justice to his citizens.
* St Gregory of Nyssa's...
Epistemic status: Speculation from two decently informed advocates armed with anecdata.
Note on process: After having some version of this conversation several times and saying, “we should probably write about this publicly,” we took the less heroic route: we recorded one of our conversations, fed the transcript into an LLM, and then substantially revised the structure, substance, and framing ourselves. We will not be sharing the transcript, as it is in...
A preliminary estimate, and a request for better ones.
Summary
I believe the standard literature estimates for the number of DALYs attributable to a case of stunting are too low, largely because they don’t account for the long term effects. This means that childhood nutritional interventions that reduce the prevalence of stunting may be substantially more cost-effective than previously believed.
Epistemic status
Exploratory and back-o...
New anti-malaria treatment clears phase 3 trials.
I just found that there is a new anti-malarial alternative to artemisinin, the most common antimalarial chemical, which has successfully completed Phase 3 trials. Its nickname is GanLum and apparently has quite powerful effects:
This is an important advance because resistance to artemisinin is one of the growing concerns in the fight against malaria.
You may read more in https://www.npr.org/sections/goats-and-soda/2025/11/12/g-s1-97487/malaria-drug-new and https://www.mmv.org/newsroom/news-resources-search/phase-3-trial-next-generation-malaria-treatment-ganaplacide-lumefantrine .
Very interesting! And very hopeful! Thanks for sharing!